Stat3 chip
WebMar 21, 2024 · STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Autoimmune Disease, Multisystem, Infantile-Onset, 1 and Hyper-Ige Recurrent Infection Syndrome 1, Autosomal Dominant . Among its related pathways are IL-9 Signaling Pathways and Prolactin Signaling . WebIdentification of Novel Direct Stat3 Target Genes–The majority of the Stat3 target genes isolated by ChIP using NIH3T3 cells with a 30-min OSM stimulation have not been identified previously by microarray analyses. To confirm that we have identified novel direct Stat3 target genes, gene-specific ChIP analyses were further performed on these ...
Stat3 chip
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WebProduct Specific Information. MA1-13042 detects STAT3 from human, mouse, monkey and rat samples. MA1-13042 has been successfully used in Western blot, ChIP, immunofluorescence, immunohistochemistry (paraffin), and immunoprecipitation procedures. By Western blot, this antibody detects a 88 kDa protein. corresponding to … WebFeb 18, 2024 · Additionally, a previously generated STAT3 ChIP-seq dataset from oligodendrocytes in the brain (GEO: GSM2650746) indicated STAT3-binding sites in the same region as the Ascl1-binding sites (STAT ChIP track; Figure 5F). Taken together, these findings suggest that STAT pathway activation and/or Ascl1 binding may induce Id gene …
WebSTAT3 binding sites were found in the gene promoters for both p55α and p50α and a ChIP assay confirmed association of STAT3 with these sites . Ultimately, STAT3 was found to promote apoptosis in these cells due to upregulation of p55α and p50α, which inhibited PI3K signaling and AKT activation reducing cell signaling for survival [ 77 ].
WebCancers. STAT3 gene mutations are found in approximately one-third of cases of a blood cancer called large granular lymphocytic leukemia (LGL), which is characterized by the … WebMonoclonal Antibody for studying STAT3 (Tyr705) phosphate. Cited in 3242 publications. Validated for WB, WB, IP, IHC, IHC, IF, F, ChIP, ChIP. Available in 3 sizes. Highly specific and rigorously validated in-house, Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit Monoclonal Antibody (CST #9145) is ready to ship.
WebApr 13, 2024 · Upon activation, STAT3 proteins are tyrosine-phosphorylated (pY 705 STAT3) by JAK, dimerize, and translocate to the nucleus where they regulate transcription. 12 …
WebJun 12, 2024 · STAT3 is a transcription factor regulating genes for cell survival, proliferation and metabolism [ 13, 14 ]. Interestingly, STAT3 can also enter the mitochondria to … bob fahrrad shopWebNational Center for Biotechnology Information clip art for numbers 1 to 20WebSTAT3 associates with Glut5 promoter and activates Glut5 transcription in response to IL-6. (A-B) DU145 and HSC-3 cells were stimulated with IL-6 (50 ng/mL) for the indicated periods of time. bob fair artWebNov 27, 2024 · STAT3-induced RORγt represses cytotoxic genes by inhibiting the functions but not the expression of the “cytotoxic” transcription factors T-bet and Eomesodermin. Thus, the transcriptional circuitry directing IL-17 expression inhibits cytotoxic functions. clip art for nutritionWebMar 8, 2024 · STAT3 ChIP-seq results showed a total of 611 and 2,289 differential STAT3-binding sites in human B cell after TLR7 and TLR9 agonists stimulation, respectively. RNA-seq results showed 1,186 and 1,775 differentially expressed genes after TLR7 and TLR9 activation, respectively. bob fahrer olympia 2022WebSTAT3 is activated in multiple tumor types. This activation enhances tumor cell survival mediated by multiple mechanisms including enhanced levels of prosurvival genes (e.g., … clip art for obituary programsWebChIP Instrument model Illumina Genome Analyzer II Description ChIP against STAT3 Data processing For ChIP-Seq and RNA-Seq, Basecalls performed using CASAVA 1.8 Raw reads were aligned to the mm9 genome assembly using Bowtie 0.12.9 Aligned reads are converted to BED format and removed redundancies using unpublished python and perl scripts clipart for obituary