Prolyl 4-hydroxylase subunit alpha 2
WebHydroxylation of Proline Residues. Prolyl 4-hydroxylase (P4H) was first identified in mammals and catalyzes the introduction of a hydroxyl group into some of the prolyl residues of collagen. 89 The 4-hydroxyproline residues are essential for the correct folding of collagen polypeptide chains. 90 P4H was the first 2-ODD to be described, and thus ... WebOct 26, 2024 · The P4H αsubunit (P4HA) is responsible for both peptide binding and catalytic activity. This process can be blocked by a number of inhibitors. Three P4HA isoforms (P4HA1-3) have been identified in...
Prolyl 4-hydroxylase subunit alpha 2
Did you know?
WebGene ID: 128050340, updated on 28-Feb-2024. Summary Other designations. prolyl 4-hydroxylase subunit alpha-2 WebNov 17, 2024 · Objective: To analyze the Prolyl 4-Hydroxylase subunit Alpha-2 (P4HA2) expression in Lung Adenocarcinoma (LAUD). Methods: The authors assessed P4HA2 …
WebProlyl 4-hydroxylase subunit alpha-2 EC number EC:1.14.11.2 ( UniProtKB ENZYME Rhea) 1 publication Short names 4-PH alpha-2 Alternative names Procollagen-proline,2 … WebJan 14, 2011 · The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer. J Biol Chem. 1997 Jul 11;272(28):17342-8. Nokelainen M, Nissi R, Kukkola L, Helaakoski T, Myllyharju J: Characterization of the human and mouse genes for the alpha subunit of type II prolyl 4-hydroxylase.
WebOct 11, 2001 · The best characterized prolyl-4-hydroxylases modify collagen as it matures along the exocytotic pathway . These enzymes are typically composed of two α and two β subunits, with the α subunit responsible for the prolyl hydroxylase activity. Three lines of evidence rule out these enzymes as the HIF prolyl hydroxylase. WebMar 19, 2024 · This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The …
WebJan 1, 2024 · Prolyl 4-Hydroxylase subunit Alpha-2 (P4HA2) is a component of the prolyl 4-hydroxylase family, a key enzyme in collagen synthesis, and is composed of two identical …
WebOct 3, 2024 · Disclosed are methods and compositions for treating cardiovascular diseases including cardiomyopathy and heart failure. Particularly disclosed are methods and compositions that utilize or comprise inhibitors of hypoxia-inducible factor (HIF)-2α or agonists/inducers of HIF prolyl hydroxylase domain-2 (PHD2) signaling for treating … co to jest sankiWebProtein target information for Prolyl 4-hydroxylase subunit alpha-1 (chicken). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. co to jest sanktuariumWebJan 2, 2014 · All known vertebrate collagen prolyl-4-hydroxylases are α2β2 tetramers consisting of two α subunits and two β subunits. Each α subunit contains the peptide … co to jest sanepidWebProcollagen-proline dioxygenase, commonly known as prolyl hydroxylase, is a member of the class of enzymes known as alpha-ketoglutarate-dependent hydroxylases.These … co to jest sarkazmco to jest sanatoriumWebMar 21, 2024 · P4HB (Prolyl 4-Hydroxylase Subunit Beta) is a Protein Coding gene. Diseases associated with P4HB include Cole-Carpenter Syndrome 1 and Cole-Carpenter Syndrome . Among its related pathways … co to jest sap bwWeb产品描述. The ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of samples in serum, Plasma , Urine ,tissue homogenates and Cell culture supernates and Other biological fluids. 储存条件. Store unopened kit at 2-8 °C for1 week. co to jest sap erp