Parsylated
Web1 Nov 2011 · In PARsylation-directed ubiquitination of axin, RNF146 directly recognize PARsylated substrates via its PAR-binding motif in WWE domain and recruit E2 via its ring … Web3 Dec 2014 · PARsylation is directed at the BRCA1 DNA binding domain and downmodulates its function. Moreover, RAP80 contains a poly-ADP-ribose–interacting domain that binds …
Parsylated
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Webconsisting of PARsylated TFEB and β-catenin-TCF/LEF1. Introduction The basic helix-loop helix leucine zipper transcription fac-tor EB (TFEB) is a member of the microphthalmia- WebMoreover, RAP80 contains a specific poly-ADP-ribose (PAR) interacting domain that binds PARsylated BRCA1. This interaction is responsible for retaining BRCA1 in IR-induced nuclear foci (IRIF) upon the completion of its normal HRR activity, and for preventing excessive HRR. Loss of both RAP80 and BRCA1 PARsylation resulted in the persistent ...
WebProgressive degeneration of dopaminergic neurons characterizes Parkinson’s disease (PD). This neuronal loss occurs through diverse mechanisms, including a form of programmed cell death dependent on... WebE3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation ( PubMed: 21478859, …
WebProject : PARsylated TFEB by TNKS1 regulates its nuclear translocation and target gene recognition. UKJIN LEE. E mail : [email protected]. Project : identification of O … Web5 Oct 2024 · The PARsylated protein is then recognized by the E3 ligase, and targeted for ubiquitination and proteasomal degradation (15,16,26). Tankyrase activity TNKS1 is phosphorylated by PLK1, glycogen synthase kinase 3 (GSK3), and MAPK, although the precise functions of this modification are not clear ( 34 – 36 ).
WebE3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by ...
WebRESEARCH Open Access Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner Alex Lyakhovich1,2†, Maria Jose Ramirez1,3†, Andres Castellanos1, Maria Castella1,3,4, Amanda M Simons5, Jeffrey D Parvin5,6, Jordi Surralles1,3* Abstract scoutbook yptWeb22 Mar 2024 · The PARsylated TFEB was bound to TCF/LEF1-β-catenin, thus explaining the different profile of TFEB-mediated Wnt target genes from the profile of genes induced by TCF/LEF1-β-catenin or the... scoutbooks.orgWebMoreover, RAP80 contains a poly-ADP-ribose-interacting domain that binds PARsylated BRCA1 and helps to maintain the stability of PARP1-BRCA1-RAP80 complexes. BRCA1 … scoutbook ypt trainingWebspecifically PARsylated by Tankyrase 1 and 2 (also called PARP 5a and 5b) which promotes Axin1 degradation through the ubiquitin proteasome pathway [12]. Unlike the … scoutbook websiteWebWe have also found that PARP1 promotes PARsylation of the BRCA1 DNA-binding domain and physiologically downmodulates BRCA1’s DNA binding and HRR activity. This process … scoutcam fundingWeb21 Mar 2024 · RNF146 (Ring Finger Protein 146) is a Protein Coding gene. Diseases associated with RNF146 include Cherubism and Arthrogryposis, Renal Dysfunction, And … scoutcam israelWebIn vitro, TNKS2 catalyzes the addition of ADP-ribosyl groups to the TBD fragment of AXIN1, while in vivo, both exogenous GST-AXIN1 and endogenous AXIN1 are PARSylated in a … scoutbugs.com