2024 Klf4 microglia

Klf4 microglia

Author: mjec

August undefined, 2024

WebMicroglia have been recognized as macrophages of the central nervous system (CNS) that are regarded as a culprit of neuroinflammation in neurodegenerative diseases. Thus, microglia have been considered as a cell that should be suppressed for maintaining a homeostatic CNS environment. However, microglia ontogeny, fate, heterogeneity, and … WebNov 12, 2024 · For exam- ple, KLF4 inhibits ischemic stroke-induced apoptosis of cere- bral microvascular endothelial by activating MALAT1 (30). Moreover, KLF4 is a key regulator of macrophage polarization (18) and can regulate microglial activation and subsequent neu- roinﬂammation(16).

TLR4-activated microglia require IFN-γ to induce severe neuronal ...

WebApr 3, 2024 · Sci Transl Med: The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration ... Klf4, and c-Myc induces rejuvenation and reduces aged-cell phenotypes. In this study, we found that transcriptional activation of the endogenous Oct4 gene by using the CRISPR/dCas9 … WebAug 9, 2024 · KLF4 has been suggested to facilitate the recruitment of transcriptional machinery even to genes within compact chromatin. 31 With KLF4 transactivation of Ch25h in the context of atheroprotective flow, we next examined the epigenetic modulations involved in such activation of the Ch25h gene. dushore founders day 2021

Exosome-based nanoimmunotherapy targeting TAMs, a promising …

WebApr 15, 2006 · Since KLF4 interacts with p300 and recruitment of co-activators to the transcriptional apparatus is a common method transcription factors use to activate gene expression, we decided to study what effect KLF4/p300 interaction would have upon expression of known KLF4 target genes. WebMay 6, 2024 · KLF4 is expressed in a variety of cell types including monocytes/macrophages. Previous reports have demonstrated that KLF4 is expressed in microglia and functions as a downstream factor of TLR signaling, plays critical roles in microglial activation, and ensuing neuroinflammation [ 38, 39, 40, 41 ]. Webthe role of Klf4 in IL-1b mediated microglial activation. Therefore we focused on IL-1b mediated Klf4 production in murine microglia and sought to understand the role of Klf4 on downstream production of key inﬂammatory markers. Although, a myeloid speciﬁc Klf4 knockdown model has been described recently (Liao et al. 2011), there are no dushore fire company dushore pa

LncRNA MEG3 regulates microglial polarization through …

Krüppel-like factor 4, a novel transcription factor regulates ... - PubMed

WebMay 9, 2016 · Interaction of malignant glioma cells and microglia. Schematic summary of experimental data revealed that malignant brain tumors secrete the cytokine MIF, which … WebNov 1, 2024 · KLF4 regulates various cell signaling pathways associated with several processes, including the PI3K/AKT pathway [19]. Serotonin 1A receptor (5HT1A) receptors … duwa construction \u0026 roofing kalonaWebApr 7, 2024 · KLF4 is shown to repress arterial inflammation to regulate neointimal formation following vascular injury by inhibiting tumor necrosis factor-α-induced expression of VCAM- 1 [ 11 ]. KLF4 is also found to be upregulated in the brain following ischemic injury [ … dushore funeral home

"WebMay 28, 2024 · KLF4 was found to cooperate with STAT6 to induce an M2 genetic program and inhibit M1 targets via sequestration of coactivators required for NF-κB activation . … " - Klf4 microglia

Klf4 microglia

LncRNA MEG3 regulates microglial polarization through KLF4 …

WebApr 3, 2024 · Microglia, a population of resident macrophages derived from erythro-myeloid progenitors of the yolk sac ... AHR enhances KLF4 expression and suppresses NF-κB signaling in TAMs. WebMay 5, 2024 · Microglia are resident macrophage-like immune cells in the central nervous system (CNS) that are important for maintaining homeostasis and normal function of the CNS. Microglia regulate multiple aspects of inflammation, such as cytotoxicity, regeneration, repair and immunosuppression depending on their activation states or phenotypes [10].

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WebApr 14, 2024 · 102.KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress. ... 191.Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses.

WebApr 12, 2024 · HIGHLIGHTS. who: Nikita Arnst et al. from the Department of Biomedical Sciences, University of Padova, Padua, Italy have published the article: Mitochondrial Ca2+ Signaling and Bioenergetics in Alzheimeru2024s Disease, in the Journal: Biomedicines 2024, 10, 3025. of /2024/ what: In this review the authors focused on Ca2+ alterations in AD … WebSep 21, 2024 · KLF4 plays a crucial role in regulating pro-inflammatory signals. In glial cells, gemfibrozil-induced KLF4 activation increases suppressor of cytokine signal 3 (SOCS3) …

WebJun 4, 2024 · KLF4 is important for many different physiological processes, including cell development, stem cell self-renewal, and maintenance of normal tissue homeostasis ( 19 ). Recently, KLF4 has been identified directly bind to promoter region of Agr1, then accelerate its transcription and microglial M2 polarization. WebDec 22, 2015 · LPS has been widely used to study the molecular mechanisms of microglial activation in inflammatory neurodegeneration (1–3).In primary monocultures and …

Web而且，meg3 与 klf4 结合并抑制其蛋白质表达。此外，meg3 的过表达促进了 m1 极化和炎症，但通过抑制 bv2 细胞中的 klf4 来抑制 m2 极化。针对 meg3 的小干扰 rna 的转染在体外和体内抑制 m1 极化和炎症并促进 m2 极化。

WebAug 9, 2013 · KLF4 inhibited the formation of a vascular network in implanted Matrigel plugs in nude mice. Importantly, we found that KLF4 significantly upregulated the miR-15a … duwa auctions iowaWebSep 21, 2024 · KLF4is a zinc finger-containing nuclear protein, isolated from NIH 3T3 library and located in the cell nucleus. It was first identified and characterized by Shields et al. (1996). The molecular mass of human KLF4is 55kD and it is located on the chromosome 9q31. KLF4covers a 6.3 kb gene segment and has five exons. duwa\u0027s auction service - wellmanWebDec 11, 2024 · We discovered that inhibition of MEG3 could alleviate cerebral I/R injury via inhibiting M1 polarization and promoting M2 polarization through Krüppel-like factor 4 (KLF4), indicating an effective theoretical basis for potential therapeutic targets of cerebral I/R injury. Back to Top Download PDF Metrics dushore newsWebDec 1, 2024 · Studies also have showed that KLF4 is a response factor for SCI and expresses higher level than that of sham animals [ 8 ]. The involvement of KLF4 in SCI may be its regulatory role in microglial activation and subsequent neuro-inflammation [ 9 ]. Moreover, the therapeutic strategy targeting on KLF4 abrogates microglial activation [ 10 ]. duwa construction \\u0026 roofing kalonaWebNational Center for Biotechnology Information dushore pa chamber of commerceWebSep 21, 2024 · KLF 4 is a zinc finger-containing nuclear protein, isolated from NIH 3T3 library and located in the cell nucleus. It was first identified and characterized by Shields et al. (1996). The molecular mass of human KLF 4 is 55kD and it is located on the chromosome 9q31. KLF 4 covers a 6.3 kb gene segment and has five exons. dushore library hoursWebApr 15, 2024 · The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB Signaling Pathway - ScienceDirect … dushore pa founders day 2022