WebWithin the sesquiterpene quinol structures, dysiherbols A–C possess an intriguing 6/6/5/6-fused tetracyclic carbon skeleton. The NF-κB inhibitory and cytotoxic activity evaluation disclosed that dysiherbol A (1) showed potent activity with respective IC₅₀ values of 0.49 and 0.58 μM, which were about 10-fold and 20-fold more potent than ... WebWithin the sesquiterpene quinol structures, dysiherbols A–C possess an intriguing 6/6/5/6-fused tetracyclic carbon skeleton. The NF-κB inhibitory and cytotoxic activity evaluation …
Enantioselective Total Synthesis and Structural …
WebSep 20, 2024 · Cycloaurenones A–C (8 a–c) feature a cis-decalin moiety, whereas the dysiherbols (9 a–c) show trans fusion of the A/B rings (Figure 1).They also differ in their absolute configuration. These compounds are biogenetically related to other natural products isolated from sponges, such as (+)-smenoqualone, 18 ilimaquinone, 19 and … WebMay 12, 2024 · In 2016 Jiao et al. reported the isolation and structural elucidation of dysiherbols A–C (1–3) and dysideanone E (4) as metabolites of the sponge Dysidea sp. … georgie girl the movie
Enantioselective Total Synthesis and Structural Revision of …
WebA synthetic study on the construction of the tetracyclic core structure of dysiherbols A–C is presented herein. In this synthesis, intramolecular [2 + 2] cycloaddition introduces a fused 6/4 ring system, followed by a Pd-catalyzed semipinacol rearrangement/C sp2 –H arylation cascade to construct the ring C, and visible-light-mediated ring-opening of cyclopropyl … WebSep 1, 2009 · A synthetic study on the construction of the tetracyclic core structure of dysiherbols A-C is presented herein. In this synthesis, intramolecular [2 + 2] cycloaddition introduces a fused 6/4 ring … Expand. 2. Save. Alert. C-C Bond Cleavage Approach to Complex Terpenoids: Development of a Unified Total Synthesis of the Phomactins. WebWe report here a concise and divergent enantioselective total synthesis of the revised structures of marine anti-cancer sesquiterpene hydroquinone meroterpenoids (+) … georgie heath height