Camptothecin drug
WebNov 29, 2024 · Camptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TOP1) to a cell poison with the potential to damage DNA by increasing the half-life of TOP1-DNA cleavage complexes (TOP1cc), … WebBackground: Poly (lactic- co -glycolic acid) (PLGA) has emerged as a promising anticancer drug delivery scaffold. Camptothecin (CPT) has been fabricated into a variety of nano-sized formulations to improve drug action. We report an experimental study on the effect of CPT-encapsulated PLGA (PLGA-CPT) nanoparticles (NPs) on drug-metabolizing ...
Camptothecin drug
Did you know?
WebJan 7, 2024 · We reported previously that this is likely due to the hydrolysable nature of the linker and the 96-hour assay timeframe which would result in the release of the coupled … WebCamptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by …
WebJul 16, 2024 · The Organized Crime Drug Enforcement Task Forces (OCDETF) investigation, dubbed Operation Monroe Doctrine, identified a methamphetamine … WebDesign, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo Authors Guorui Zhang 1 , Ruijuan Yin 2 , Xiufei Dai 1 , Guanzhao Wu 3 , Xin Qi 1 , Rilei Yu 2 , Jing Li 4 , Tao Jiang 5 Affiliations
WebFeb 6, 2024 · Numerous attempts to overcome the poor water solubility of cam ptothecin (CPT) by various nano drug delivery systems are described in various sources in the …
WebAug 15, 2024 · Abstract. Camptothecins (CPT) are an important class of molecules that have been employed in cancer therapy for the past 20 years. These molecules interact with the DNA-topoisomerase I complex leading to double-strand breaks and cell death. While these molecules are important cancer therapies, they also induce toxicities including …
WebMay 13, 2015 · In continuation of our program aimed at the development of natural product-based pesticidal agents, three series of novel camptothecin derivatives were designed, synthesized, and evaluated for their biological activities against T. Cinnabarinus, B. brassicae, and B. xylophilus. All of the derivatives showed good-to-excellent activity … blacklight directorWebFeb 15, 2024 · 20- ( S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA topoisomerase 1 poison with an interesting antitumor activity and its use is limited by low stability and solubility and unpredictable drug-drug interactions. gansen subdivision shorewoodWebJun 13, 2024 · Camptothecin is a potent anticancer drug which inhibits the enzyme, deoxyribonucleic acid topoisomerase I, during the S-phase of cell cycle (Zunino et al. … black light dinner party we are goldenWebAug 31, 2024 · We report a camptothecin (CPT) prodrug that was well formulated in solution and rapidly transformed into long-circulating nanocomplexes in vivo for highly efficient drug delivery and effective cancer therapy. Specifically, using a redox-responsive disulfide linker, CPT was conjugated with an albumin-binding Evans blue (EB) derivative; … ganser holocaustWebCAMPTOTHECIN chembl:CHEMBL65 Antineoplastic Alternate Names: Drug Info: ChemblDrugs DTC TdgClinicalTrial ClearityFoundationClinicalTrial (3 More Sources) Publications: Costa-Pereira et al., 2000, Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis., Br. J. … ganse pharmacy lancaster paWebCamptothecin (CA), an alkaloid with a peculiar anticancer mechanism, acts with a unique mechanism of action, targeting the nuclear enzyme topoisomerase I (Yang et al., 1999 ). CA inhibits the growth of a wide range of tumors ( Giovanella et al., … blacklight distributionWebCamptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA … ganseforth wilhelmshaven